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KMID : 1200020130370030207
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Diabetes & Metabolism Journal
2013 Volume.37 No. 3 p.207 ~ p.211
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Beneficial Effects of Omega-3 Fatty Acids on Low Density Lipoprotein Particle Size in Patients with Type 2 Diabetes Already under Statin Therapy
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Lee Myung-Won
Park Jeong-Kyung
Hong Jae-Won
Kim Kwang-Joon
Shin Dong-Yeob
Ahn Chul-Woo
Song Young-Duk
Cho Hong-Keun
Park Seok-Won
Lee Eun-Jig
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Abstract
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Beyond statin therapy for reducing low density lipoprotein cholesterol (LDL-C), additional therapeutic strategies are required to achieve more optimal reduction in cardiovascular risk among diabetic patients with dyslipidemia. To evaluate the effects and the safety of combined treatment with omega-3 fatty acids and statin in dyslipidemic patients with type 2 diabetes, we conducted a randomized, open-label study in Korea. Patients with persistent hypertriglyceridemia (≥200 mg/dL) while taking statin for at least 6 weeks were eligible. Fifty-one patients were randomized to receive either omega-3 fatty acid 4, 2 g, or no drug for 8 weeks while continuing statin therapy. After 8 weeks of treatment, the mean percentage change of low density lipoprotein (LDL) particle size and triglyceride (TG) level was greater in patients who were prescribed 4 g of omega-3 fatty acid with statin than in patients receiving statin monotherapy (2.8%±3.1% vs. 2.3%±3.6%, P=0.024; -41.0%±24.1% vs. -24.2%±31.9%, P=0.049). Coadministration of omega-3 fatty acids with statin increased LDL particle size and decreased TG level in dyslipidemic patients with type 2 diabetes. The therapy was well tolerated without significant adverse effects.
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KEYWORD
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Diabetes mellitus, type 2, Dyslipidemia, Fatty acids, omega-3, Hypertriglyceridemia, Low density lipoprotein particle
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